structural studies of the functional complexes of the 50s and 70s ribosome a major antibiotic target
Báo cáo Y học: Structural studies on the core and the O-polysaccharide repeating unit of Pseudomonas aeruginosa immunotype 1 lipopolysaccharide pot
... biological repeating unit, and the site and the mode of the attachment of the O-polysaccharide to the core belongs to serogroup O6 of the international antigenic typing system (IATS) and is characterized ... [4,5] As in the LPS of P aeruginosa O5 [4], in the LPS of immunotype (serogroup O6) the terminal fi 3-linked Rha residue of the core oligosaccharide is the site of the attachment of the O-polysaccharide ... O-acetylation site and the O-acetyl group is present in the core of a minority of the LPS molecules The position of the O-acetyl groups in the core of P aeruginosa LPS, as well as their biological...
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Synthetic and structural studies of copper, gold and palladium heterocyclic carbene complexes
... inactive metal occurs in the absence of a stabilizing ligand This highlights the importance of the stabilizing phosphine and NHC ligands in this field.41 Therefore the application of gold NHC complexes ... are reports on the catalytic activities of NSHC complexes, there is still a general lack of systematic and parallel studies of NSHC and other NNHC counterparts The immense potential of NSHC complexes ... prepared via the alkylation method in 1994.71 (Scheme 1.3) The X-ray structure of I-23 indicates that the copper atom bonds to the carbene carbon of the thiazolylidene ligand and the two bridging...
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Báo cáo khoa học: Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase doc
... in the active site The interactions of the deoxyribose and the base are identical to those of the dT complex, except for the fluoride atom replacing the methyl group on the base (Fig 2A) In the ... owing to the loss of hydrogen bonds The substitution of the 3¢-oxygen with an azide group in AZT apparently destabilized part of the structure The only substitutions of the pyrimidine ring of the ... Surprisingly, there were two sulfate ions present – one bound in the P loop, as observed in the other substrate complexes, and the other located between the first sulfate ion and the substrate There Nucleoside...
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Tài liệu Báo cáo khoa học: "Predicting the fluency of text with shallow structural features: case studies of machine translation and human-written text" doc
... gold-standard Yet, the assessments of the two aspects were often the same—readability/fluency of the sentence is important for understanding the sentence Only after the assessor has understood the ... better understand which factors are predictive of good fluency The distribution of fluency scores in the dataset is rather skewed, with the majority of the sentences rated as being of average fluency ... with the idea that these are qualities of the translations that are independent of each other Fluency was judged directly by the assessors, while adequacy was meant to assess the content of the...
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Báo cáo khoa học: Structural studies of the capsular polysaccharide and lipopolysaccharide O-antigen of Aeromonas salmonicida strain 80204-1 produced under in vitro and in vivo growth conditions docx
... comparison of its MS with that of the reference compound The absolute configuration of glycoses was established by capillary GLC of their acetylated (-)-2-butyl glycosides, according to the method of ... stainless steel needle (27 g) was butted against the low dead volume tee and enabled the delivery of the sheath solution to the end of the capillary column The separations were obtained on 90-cm long ... amount of 2-amino-2deoxy-D-galactose was identified in the hydrolysis products of both carboxyl-reduced CPS and LPS [19], confirming the presence of GalNAcA in the native CPS and LPS This was further...
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Tài liệu Báo cáo khoa học: Mutational analysis of plasminogen activator inhibitor-1 Interactions of a-helix F and its neighbouring structural elements regulates the activity and the rate of latency transition pdf
... 5), and the salt-bridge between E132 and R135 [18] contribute to the thermodynamic stability of the stressed conformation and/ or are important for the positioning of hF in a way delaying the ... mimicking the effect of the K325A substitution (Fig 5) Of note is that the side chain of E285 forms a hydrogen bond to the backbone of the hF/s3A-loop in PAI-1stab [18] (Fig 5) and in contrast with the ... phenotypes of PAI-1(N139A), PAI-1(T146A), and the close spatial proximity and similar structural role of N139 and T146, we find it likely that the structures of these variants, with the RCL exposed,...
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Báo cáo khoa học: Insertion of the plant photosystem I subunit G into the thylakoid membrane In vitro and in vivo studies of wild-type and tagged versions of the protein doc
... topology where the loop is in the thylakoid lumen, and the N -and C-termini face the stroma, opposite to that of PSI-K On the other hand, the second scenario implies a stromal loop, like that of PSI-K, ... of their crystal structure of Pisum sativum PSI, in which the loop of PSI-G is suggested to face the stroma The amount of PSI-G in the transformed knock-out line does not reach the level of the ... integration of the subunit into the PSI complex A protein band smaller that the tagged versions of PSI-G is present in the lanes with the loop-tagged PSI, but is also seen faintly in the lanes with the...
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Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... in the range 15) 60 C The results of the analysis of these curves using the linear extrapolation model (LEM) are shown in Tables and and Fig 4AC There is a slight temperature dependence of the ... structure, on the basis of their percentage contributions (65% and 35%, respectively) to the overall structure of the protein The structures of the major and minor conformations of holo-ACP bear close ... estimated on the basis of the linear regression of the fraction number of the molecular mass markers cytochrome c (CyC), carbonic anhydrase (CA), and BSA From the calibration curve of the sucrose...
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Báo cáo khoa học: Characterization of oligosaccharides from the chondroitin/dermatan sulfates 1 H-NMR and 13 C-NMR studies of reduced trisaccharides and hexasaccharides doc
... allowing an understanding of species, tissue, age and pathology related differences and the estimation of changes in CS ⁄ DS abundance and composition However, the reduction of the polymer to its individual ... sources, from tissues of differing ages and also within a single chain Enhanced availability of data to facilitate the characterization of these structures is therefore of value GAGs are not ... AC and ABC lyases generate disaccharides and tetrasaccharides [4] and have been widely used for the analysis of CS ⁄ DS composition These studies have yielded crucial data allowing an understanding...
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STUDIES ON THE ECOLOGY AND CONSERVATION OF BUTTERFLIES IN EUROPE: Vol. 1: General Concepts and Case Studies pptx
... Europe 15 Studies on the Ecology and Conservation of Vol 1: General Concepts and Case Studies, p 15 Consequences of the spatial configuration of resources for the distribution and dynamics of the endangered ... that the presence of Clouded Apollo was significantly dependent on the number of fumewort, on the heterogeneity of landscapes, and on the presence of semi-natural grasslands, deep valleys and ... 12(10%) and from the earlier period 19(16%) records There are three main centres of Clouded Apollo in Estonia: the population of the island of Saaremaa, and the North-Estonian and the South-Estonian...
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Báo cáo khoa học: Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III ppt
... Hlouchova et al of the S1-bound chloride anion and ‘pushes’ the Cl) out of the bottom of the S1 pocket (the occupancy of the Cl) in this structure is 0.7) The alternate conformation of the Asp443 ... with the occupancy of the S1 pocket by a ligand and the ‘open–close’ transition exploits the hinges on the two sides of the lid made up of Asn540 ⁄ Trp541 and Gly548 (GCPII numbering) In the GCPIII ... Asn628-NAG2 of one monomer and the side chain of Glu266 of the apical domain of the second monomer The binuclear metal center Electron density maps reveal the presence of two metal ions in the active...
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báo cáo khoa học: " Characterization and structural analysis of wild type and a non-abscission mutant at the development funiculus (Def) locus in Pisum sativum L" pdf
... drafting of the manuscript MA contributed with plant material, the general idea of the study and participated in revision of the manuscript AKHE participated in the general idea of the study, the ... contrast to the wild type, seeds of the mutant had a slightly thickened funicle Furthermore both the proximal and distal ends of the funicle remain firmly attached to the seed coat and the pod wall, ... controlling the abscission event of pea seeds Absence of the hilum palisade layers is the key characteristic in the def mutant pea seed Structural analysis revealed the absence of the palisade layer and...
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báo cáo khoa học: " Selection of reference genes for quantitative real-time PCR expression studies in the apomictic and sexual grass Brachiaria brizantha" ppt
... on the geometric mean of the expression values of the set of the control genes tested The lower the M value, the more stably expressed the gene is Also, the program enables the exclusion of the ... value of all the other genes and also a change in the M values of the unstable genes, BbrizGDP and BbrizUBI (Figure 3b) To check if the Figure Box-whisker showing the Ct variation of each candidate ... factor-1 alpha (BbrizEF1), and showed the narrowest Ct range and therefore the least deviation from the Ct median by the different samples (Figure 1) The Ct values of the candidate reference genes...
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Báo cáo khoa học: "Comparative studies on the pathogenicity and tissue distribution of three virulence variants of classical swine fever virus, two field isolates and one vaccine strain, with special regard to immunohistochemical investigations" ppt
... immunohistochemical and in situ hybridisation studies, participated in the evaluation and summarizing of the findings and wrote the draft of the manuscript FK applied for funding of the project, participated ... group The hybridisation signals were observed in the cytoplasm of the epithelial (Figure 8), mononuclear and reticular cells When using the probe on the sections of the uninfected animals or the ... was either a technical problem, or the amount of vaccine virus was so low that it was under the level of the detection capacity of the VI test in quite a number of animals As further tools of direct...
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In vitro and in vivo studies into the antidiabetic and antilipidemic effects of chlorogenic acid
... before the initiation of chornic treatment and at the end of the study Blood sample, pancreas, liver and soleus muscle were collected at the end of the study and frozen at -80°C till the time of ... Acute 50g 17 1.8 Coffee and diabetes The present study has greatly been inspired by the studies of the correlation between coffee and diabetes To date, a total of 13 cohort studies involving ... the goal of cost-effective management with minimal complications but maximal quality of life Before the introduction of the therapeutic use of insulin, diet 11 is the main form of treatment of...
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Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation body
... neurons in the hilus and CA3 area, comprise the second synapse of the hippocampal circuit In this trisynaptic model of the hippocampus, based on the observations of the MFs presynapses and their locations, ... in the studies in Part I of this thesis: To detect the in vivo progressing of the MFs remodelling during the spatial memory formation using the MEMRI approach In addition, the issue whether the ... groups: 10 of the Wistar and 13 of the LH rats in a training group to find the hidden platform, 10 of Wistar and 13 of LH rats were yoked swim controls, and of each strain were housed controls The swim...
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Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation
... redistribution of the hippocampal MFs that is induced by spatial learning In the second study, the laminar-specific Zn levels in the synapses from MFs to CA3 region of the hippocampus have been mapped and ... concentrations and standard errors of Fe Cu and Zn in different layers and background levels, based on seven sections from seven rats 100 List of Figures Figure 1.1 Basic anatomy of the hippocampus ... Introduction of the hippocampus……………………………… 1.1.1.2 Introduction of the mossy fibers………………………………… 1.1.2 Histology of Mossy fiber pathways……………………………………… 1.1.3 Anatomic plasticity of the mossy fibers……………………...
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Computational studies of host pathogen protein protein interactions a case study of the h sapiens m tuberclulosis H37RV system
... unconditional love, understanding and support Their love and support are the source of motivation and happiness in my life Finally, I appreciate the friendship and support of our current and former group ... ancestral pair of interacting proteins and is expected to inherit the structure and function and, thus, interactions of the ancestral proteins Therefore, the basic procedure of the homology-based ... GO assessment of the top 839 PPIs predicted by the stringent and the conventional DDI-based approaches Informative GO assessment of the top 839 PPIs predicted by the stringent and the conventional...
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Structural studies of glycogen branching enzyme (GLGB) CRFE2alpha urucortin complexes
... Fourier transformation (FT) of f(x), and the unit of the variable h is the reciprocal of the unit of x The Fourier transform operation is reversible That is, the same mathematical operation that ... of the ligand-free and ligand-bound states of CRFR1 and CRFR2α 103 Figure 7.10 Binding of Ucn1/3 native and mutated peptides to the CRFR1 and CRFR2α ECDs 105 Figure 7.11 Comparison of the CRFR2α ... possible for the first credible breadth of the mycobacterial literature, but time to establish the complete proof of the parasitic nature of a human infectious disease, and this of the most important...
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